We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Androgens and Dry Eye in Sjögren's Syndrome<sup>a</sup>.
- Authors
SULLIVAN, DAVID A.; WICKHAM, L. ALEXANDRA; ROCHA, EDUARDO M.; KRENZER, KATHLEEN L.; SULLIVAN, BENJAMIN D.; STEAGALL, REBECCA; CERMAK, JENNIFER M.; DANA, M. REZA; ULLMAN, M. DAVID; SATO, ELCIO H.; GAO, JIANPING; ROCHA, FLAVIO J.; ONO, MASAFUMI; SILVEIRA, LILIA A.; LAMBERT, ROSS WILLIAM; KELLEHER, ROBIN S.; TOLLS, DOROTHY BAZZINOTTI; TODA, IKUKO
- Abstract
ABSTRACT: Sjögren's syndrome is an extremely complex and currently incurable autoimmune disorder, which occurs primarily in females, and is associated with lacrimal gland inflammation, meibomian gland dysfunction, and severe dry eye. We hypothesize that androgen deficiency, which reportedly occurs in primary and secondary Sjögren's syndrome (e.g., systemic lupus erythematosus, rheumatoid arthritis), is a critical etiologic factor in the pathogenesis of dry eye syndromes. We further hypothesize that androgen treatment to the ocular surface will promote both lacrimal and meibomian gland function and alleviate both 'aqueous-deficient' and 'evaporative' dry eye. Our results demonstrate that androgens regulate both lacrimal and meibomian gland function, and suggest that topical androgen administration may serve as a safe and effective therapy for the treatment of dry eye in Sjögren's syndrome.
- Publication
Annals of the New York Academy of Sciences, 1999, Vol 876, Issue 1, p312
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1111/j.1749-6632.1999.tb07656.x