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- Title
Spontaneous regression in an ulcerated CK7 positive Merkel cell carcinoma.
- Authors
Khader, Anza; George, Sandhya; Balakrishnan, Swapna; Aravindan, Karumathil Puthiaveetil
- Abstract
Merkel cell carcinoma is an aggressive and frequently lethal tumor of the elderly, associated with sun exposure and immunosuppression which is less common in the dark-skinned. We report the case of a 40-year-old woman who presented with multiple slowly progressive, mildly itchy ulcerated plaques of size ranging from 2 × 3 cm to 5 × 7 cm on the left knee of 1 year duration. Skin biopsy showed diffuse dermal infiltration by small round cells with molding of cells and lymphocyte infiltration. The cells stained positive for cytokeratin (CK) 20, CK7, neuron-specific enolase, and chromogranin. The skin lesions underwent spontaneous regression within 1 month of skin biopsy and have not recurred during the past 2 years. The immune mechanisms triggered by biopsy possibly explain the spontaneous regression.
- Subjects
KERATIN; IMMUNOSUPPRESSION; ENOLASE; CHROMOGRANINS
- Publication
Indian Journal of Dermatology, Venereology & Leprology, 2015, Vol 81, Issue 2, p170
- ISSN
0378-6323
- Publication type
Case Study
- DOI
10.4103/0378-6323.152286