We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Cell death in parasitic protozoa: regulated or incidental?
- Authors
Proto, William R.; Coombs, Graham H.; Mottram, Jeremy C.
- Abstract
Apoptosis and other types of regulated cell death have been defined as fundamental processes in plant and animal development, but the occurrence of, and possible roles for, regulated cell death in parasitic protozoa remain controversial. A key problem has been the difficulty in reconciling the presence of apparent morphological markers of apoptosis and the notable absence of some of the key executioners functioning in higher eukaryotes. Here, we review the evidence for regulated cell death pathways in selected parasitic protozoa and propose that cell death in these organisms be classified into just two primary types: necrosis and incidental death. It is our opinion that dedicated molecular machinery required for the initiation and execution of regulated cell death has yet to be convincingly identified.
- Subjects
APOPTOSIS; PARASITIC protozoa; PLANT development; EUKARYOTES; NECROSIS; MOLECULAR machinery (Technology)
- Publication
Nature Reviews Microbiology, 2013, Vol 11, Issue 1, p58
- ISSN
1740-1526
- Publication type
Article
- DOI
10.1038/nrmicro2929