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- Title
Treatment of feline intermediate- to high-grade lymphoma with a modified university of Wisconsin-Madison protocol: 119 cases (2004-2012).
- Authors
Collette, S. A.; Allstadt, S. D.; Chon, E. M.; Vernau, W.; Smith, A. N.; Garrett, L. D.; Choy, K.; Rebhun, R. B.; Rodriguez, C. O.; Skorupski, K. A.
- Abstract
CHOP-based (cyclophosphamide, doxorubicin, vinca alkaloid, prednisolone) chemotherapy protocols are often recommended for treatment of feline lymphoma. While maintenance-free CHOP-based protocols have been published and readily used in dogs, there is limited literature regarding similar maintenance-free protocols in cats. The purpose of this study was to describe the outcome of cats with intermediate- to high-grade lymphoma that were prescribed a modified 25-week University of Wisconsin-Madison ( UW-25) chemotherapy protocol. A secondary objective was examination of potential prognostic factors. One hundred and nineteen cats from five institutions treated with a UW-25-based protocol were included. The Kaplan-Meier median progression-free interval ( PFI) and survival time ( MST) were 56 and 97 (range 2-2019) days, respectively. Cats assessed as having a complete response ( CR) to therapy had significantly longer PFI and MST than those with partial or no response ( PFI 205 versus 54 versus 21 days, respectively, P < 0.0001 and MST 318 versus 85 versus 27 days, respectively, P < 0.0001).
- Subjects
LYMPHOMAS; LYMPHOMAS in animals; UNIVERSITY of Wisconsin (Madison, Wis.); CYCLOPHOSPHAMIDE; DOXORUBICIN; TREATMENT of cat diseases; KAPLAN-Meier estimator; VETERINARY therapeutics; CAT diseases
- Publication
Veterinary & Comparative Oncology, 2016, Vol 14, p136
- ISSN
1476-5810
- Publication type
Article
- DOI
10.1111/vco.12158