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- Title
The Triaging Effect of the Human Papillomavirus 16/18 E7 Oncoprotein Assay in HPV 16/18-Positive Patients for High-Grade Cervical Intraepithelial Neoplasia Screening: A Cross-Sectional Study.
- Authors
Xiao, Xiaoping; Cao, Yang; Bi, Kaihua; Wang, Wei; Yang, Junjun; Wang, Jinhui; Li, Yan; Li, Caijuan; Guan, Ruoli; Zhang, Ying; Wang, Jin; Song, Shuhui; Zhu, Lan; Shi, Honghui
- Abstract
Objective: To investigate the triaging efficacy of the human papillomavirus (HPV) 16/18 E7 oncoprotein assay for high-grade cervical intraepithelial neoplasia (CIN2+) screening in HPV 16/18-positive patients in a tertiary hospital in China. Methods: We collected 476 cervical cell samples from women who tested positive for HPV 16/18 in the gynecological clinic of Peking Union Medical College Hospital between September 2018 and September 2022 and analyzed them by the HPV 16/18 E7 oncoprotein assay before colposcopy and biopsy. The study assessed the triaging efficacy of the HPV 16/18 E7 oncoprotein assay in HPV 16/18-positive patients by analyzing its performance against the gold standard of histologically confirmed CIN2+. Results: The positive rate of the HPV 16/18 E7 oncoprotein assay was 41.0% (114/278) in the negative for intraepithelial lesions and malignancy/CIN1 group and 80.3% (159/198) in the CIN2+ group. For triage of women with a positive HPV 16/18 test for CIN2+ detection, the HPV 16/18 E7 oncoprotein assay had a sensitivity, specificity, positive predictive value, and negative predictive value of 80.3%, 59.4%, 58.5%, and 80.9%, respectively. Furthermore, longitudinal follow-up of five patients showed a good correlation between the expression of the HPV 16/18 E7 oncoprotein and cervical lesion grades. Conclusions: As a triage method for HPV 16/18-positive patients, the HPV 16/18 E7 oncoprotein assay improves the specificity, reduces the colposcopy referral rate, and has the potential for long-term monitoring of high-grade CIN.
- Subjects
CHINA; PAPILLOMAVIRUSES; BIOPSY; PREDICTIVE tests; CROSS-sectional method; COLPOSCOPY; CERVICAL intraepithelial neoplasia; EARLY detection of cancer; TERTIARY care; DESCRIPTIVE statistics; TUMOR markers; SENSITIVITY &; specificity (Statistics); DATA analysis software
- Publication
Journal of Women's Health (15409996), 2023, Vol 32, Issue 10, p1136
- ISSN
1540-9996
- Publication type
Article
- DOI
10.1089/jwh.2023.0058