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- Title
Survival Benefit of Traditional Chinese Herbal Medicine (a Herbal Formula for Invigorating Spleen) for Patients With Advanced Gastric Cancer.
- Authors
Xu, Yan; Zhao, Ai Guang; Li, Zhao Yan; Zhao, Gang; Cai, Yong; Zhu, Xiao Hong; Cao, Ni Da; Yang, Jin Kun; Zheng, Jian; Gu, Yin; Han, Ying Ying; Zhu, Ying Jie; Yang, Jin Zu; Gao, Feng; Wang, Qiang
- Abstract
Background. Traditional Chinese herbal medicine (TCHM) is widely used for advanced gastric cancer (AGC) in China. In this study, the authors analyzed the prognostic factors of selected patients with AGC, and further studied the efficacy of TCHM (a herbal formula for invigorating spleen, formerly named Wei Chang’ An) on AGC. Methods. Patients with uncured AGC were prospectively enrolled. All patients were enrolled to either the TCHM group or non-TCHM group. TCHM was administered orally to the patients in the TCHM group for 3 months or more. Cox regression analysis was performed to determine survival trends adjusted for clinical and demographic factors. Kaplan–Meier curves were used to assess the differences in survival time. Results. There were a total of 399 eligible patients with histologically confirmed adenocarcinoma of the stomach from 2001 to 2009. In the overall group, Cox regression analysis suggested that histological type (P = .016), radiotherapy (P = .000), cycle of chemotherapy (P = .000), and TCHM (P = .000) were independent prognostic factors. In a stratification analysis of stage for 213 patients who received 3 or more cycles of chemotherapy, there was a significant increase in median overall survival from 14.0 (non-TCHM group) to 20.0 (TCHM group) months (hazard ratio [HR] = 0.538, 95% confidence interval [CI] 0.385-0.750, P = .000). Among 186 patients who did not receive chemotherapy, but best supportive care, there was a significant increase in median overall survival from 7.0 (non-TCHM group) to 14.8 (TCHM group) months (HR = 0.443, 95% CI = 0.299-0.657, P = .000). Conclusions. TCHM has an important potential value for improving the prognosis of patients with AGC.
- Subjects
CHINA; ACADEMIC medical centers; STOMACH tumors; CANCER chemotherapy; CHI-squared test; CONFIDENCE intervals; LONGITUDINAL method; BOTANIC medicine; CHINESE medicine; MULTIVARIATE analysis; RESEARCH funding; SPLEEN; SURVIVAL analysis (Biometry); PROPORTIONAL hazards models; DATA analysis software; DESCRIPTIVE statistics; KAPLAN-Meier estimator; PROGNOSIS; TUMOR treatment
- Publication
Integrative Cancer Therapies, 2013, Vol 12, Issue 5, p414
- ISSN
1534-7354
- Publication type
Article
- DOI
10.1177/1534735412450512