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- Title
Enantioselective Palladium‐Catalyzed Cross‐Coupling of α‐Bromo Carboxamides and Aryl Boronic Acids.
- Authors
Li, Bowen; Li, Tiejun; Aliyu, Muinat A.; Li, Zhen Hua; Tang, Wenjun
- Abstract
We herein report an enantioselective palladium‐catalyzed cross‐coupling between α‐bromo carboxamides and aryl boronic acids, generating a series of chiral α‐aryl carboxamides in good yields and excellent enantioselectivities. The development of a chiral P,P=O ligand was critical in overcoming the second transmetalation issue and allows the first asymmetric palladium‐catalyzed coupling of α‐bromo carbonyl compounds.
- Subjects
CARBOXAMIDES; BORONIC acids; CARBONYL compounds; DIALKYLZINC
- Publication
Angewandte Chemie, 2019, Vol 131, Issue 33, p11477
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201905174