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- Title
Synthesis of γ‐Boryl‐Substituted Homoallylic Alcohols with anti Stereochemistry Based on a Double‐Bond Transposition.
- Authors
Miura, Tomoya; Nakahashi, Junki; Sasatsu, Takanori; Murakami, Masahiro
- Abstract
The stereoselective synthesis of anti isomers of γ‐boryl‐substituted homoallylic alcohols is disclosed. (E)‐1,2‐Di(boryl)alk‐1‐enes undergo Ru‐catalyzed double‐bond transposition with control of the geometry. The in situ generated (E)‐1,2‐di(boryl)alk‐2‐enes add to aldehydes in a stereospecific manner. The alkenylboron group within the product is amenable to a variety of synthetic derivatizations.
- Subjects
CHEMICAL alcohol synthesis; RUTHENIUM catalysts; ALDEHYDES; DOUBLE bonds; STEREOCHEMISTRY
- Publication
Angewandte Chemie, 2019, Vol 131, Issue 4, p1150
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201811205