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- Title
A Desulfurative Strategy for the Generation of Alkyl Radicals Enabled by Visible‐Light Photoredox Catalysis.
- Authors
Xue, Fei; Wang, Falu; Liu, Jiazhen; Di, Jiamei; Liao, Qi; Lu, Huifang; Zhu, Min; He, Liping; He, Huan; Zhang, Dan; Song, Hao; Liu, Xiao‐Yu; Qin, Yong
- Abstract
Abstract: Herein, we present a new desulfurative method for generating primary, secondary, and tertiary alkyl radicals through visible‐light photoredox catalysis. A process that involves the generation of N‐centered radicals from sulfinamide intermediates, followed by subsequent fragmentation, is critical to forming the corresponding alkyl radical species. This strategy has been successfully applied to conjugate addition reactions that features mild reaction conditions, broad substrate scope (>60 examples), and good functional‐group tolerance.
- Subjects
DESULFURIZATION; ALKYL radicals; VISIBLE spectra; PHOTOCATALYSIS; SULFINAMIDES; INTERMEDIATES (Chemistry); CONJUGATE addition reactions
- Publication
Angewandte Chemie, 2018, Vol 130, Issue 22, p6777
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201802710