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- Title
Rapid Assembly of Diversely Functionalized Spiroindenes by a Three-Component Palladium-Catalyzed C−H Amination/Phenol Dearomatization Domino Reaction.
- Authors
Fan, Liangxin; Liu, Jingjing; Bai, Lu; Wang, Yaoyu; Luan, Xinjun
- Abstract
A novel palladium-catalyzed three-component reaction of phenol-derived biaryls with N-benzoyloxyamines and norbornadiene (NBD) has been developed for the assembly of highly functionalized spiroindenes. This domino process was realized through NBD-assisted C−H amination and phenol dearomatization by forming one C−N bond and two C−C bonds in a single step. Preliminary studies indicated that asymmetric control of this transformation was feasible with chiral ligands. Moreover, the potential synthetic utility of this methodology was highlighted by a series of further transformations.
- Subjects
MOLECULAR self-assembly; INDENE; PALLADIUM catalysts; CARBON-hydrogen bonds; AMINATION; PHENOL; AROMATIZATION
- Publication
Angewandte Chemie, 2017, Vol 129, Issue 45, p14445
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201708310