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- Title
Palladium-Catalyzed Enantioselective Redox-Relay Heck Alkynylation of Alkenols To Access Propargylic Stereocenters.
- Authors
Chen, Zhi‐Min; Nervig, Christine S.; DeLuca, Ryan J.; Sigman, Matthew S.
- Abstract
An enantioselective redox-relay Heck alkynylation of di- and trisubstituted alkenols to construct propargylic stereocenters is disclosed using a new pyridine oxazoline ligand. This strategy allows direct access to chiral β-alkynyl carbonyl compounds employing allylic alcohol substrates in contrast to more traditional conjugate addition methods.
- Subjects
PALLADIUM catalysts; ENANTIOSELECTIVE catalysis; HECK reaction; STEREOCHEMISTRY; OXAZOLINE; LIGANDS (Chemistry)
- Publication
Angewandte Chemie, 2017, Vol 129, Issue 23, p6751
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201703089