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- Title
Multiplex Detection of Enzymatic Activity with Responsive Lanthanide-Based Luminescent Probes.
- Authors
Pershagen, Elias; Borbas, K. Eszter
- Abstract
Multiplex analyte detection in complex dynamic systems is desirable for the investigation of cellular communication networks as well as in medical diagnostics. A family of lanthanide-based responsive luminescent probes for multiplex detection is reported. The high modularity of the probe design enabled the rapid assembly of both green and red emitters for a large variety of analytes by the simple exchange of the lanthanide or an analyte-cleavable caging group, respectively. The real-time three-color detection of up to three analytes was demonstrated, thus setting the stage for the non-invasive investigation of interconnected biological processes.
- Subjects
RARE earth metal spectra; RARE earth metal analysis; CELL communication; FLUORESCENCE; CHEMOSELECTIVITY; EXCITATION spectrum; TIME-resolved spectroscopy
- Publication
Angewandte Chemie, 2015, Vol 127, Issue 6, p1807
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201408560