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- Title
Fluxionally Chiral DMAP Catalysts: Kinetic Resolution of Axially Chiral Biaryl Compounds.
- Authors
Ma, Gaoyuan; Deng, Jun; Sibi, Mukund P.
- Abstract
Can organocatalysts that incorporate fluxional groups provide enhanced selectivity in asymmetric transformations? To address this issue, we have designed chiral 4-dimethylaminopyridine (DMAP) catalysts with fluxional chirality. These catalysts were found to be efficient in promoting the acylative kinetic resolution of secondary alcohols and axially chiral biaryl compounds with selectivity factors of up to 37 and 51, respectively.
- Subjects
ENANTIOSELECTIVE catalysis; KINETIC resolution; CHIRALITY; RESOLUTION (Chemistry); CHEMICAL research
- Publication
Angewandte Chemie, 2014, Vol 126, Issue 44, p12012
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201406684