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- Title
Urethral compensatory mechanisms to maintain urinary continence after pudendal nerve injury in female rats.
- Authors
Furuta, Akira; Suzuki, Yasuyuki; Asano, Koji; Groat, William; Egawa, Shin; Yoshimura, Naoki
- Abstract
Introduction and hypothesis: This study was conducted to investigate the urethral compensatory mechanisms to maintain urinary continence after pudendal nerve injury. Methods: In naive, acute pudendal nerve transection (PNT) and 4 weeks after PNT (PNT-4w) female rats, leak point pressures (LPPs) during bladder compression were measured before and after the application of hexamethonium (C6), propranolol, and N-nitro- l-arginine-methyl ester ( l-NAME), or terazosin and atropine. Responses to carbachol and phenylephrine of proximal and middle urethral muscle strips from naive and PNT-4w rats were also examined. Results: LPPs were significantly decreased in PNT rats but not in PNT-4w rats. LPPs in PNT rats were significantly increased by C6 or L-NAME while LPPs in PNT-4w rats were significantly decreased by C6, or terazosin and atropine. Excitatory responses to carbachol and phenylephrine in the proximal urethral muscle were significantly larger in PNT-4w rats. Conclusions: These results suggest that α-adrenoceptor and muscarinic receptor-mediated contractility is upregulated in the proximal urethra 4 weeks after PNT.
- Subjects
URETHRA; URINARY incontinence; PUDENDAL nerve; SPHINCTER surgery; URINATION; PREVENTION
- Publication
International Urogynecology Journal, 2011, Vol 22, Issue 8, p963
- ISSN
0937-3462
- Publication type
Article
- DOI
10.1007/s00192-011-1403-6