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- Title
Chemical composition, angiotensin I-converting enzyme inhibitory, antioxidant and antimicrobial activities of essential oil of Thnisian Thynius algeriensis Boiss. et Reut. (Lamiaceae).
- Authors
Zouari, Nacim; Fakhfakh, Nahed; Zouari, Sami; Bougatef, Ali; Karray, Aida; Neffati, Mohamed; Ayadi, M. A.
- Abstract
The present study describes chemical composition, angiotensin I-converting enzyme (ACE) inhibitory, antioxidant and antimicrobial activities of the essential oil of wild growing Thymus algeriensis Boiss. et Reut. (Lamiaceae), a traditional medicinal plant which is mainly endemic in Thnisia and Algeria. The essential oil from the fresh leaves and flowers of T. algeriensis were extracted by hydrodistillation and analysed by GC and GC/MS. Fifty-seven compounds were identified accounting for 97.71% of the total oil, where oxygenated monoterpenes constituted the main chemical class (44.85%). The oil was dominated by camphor (7.82%), 4-terpineol (7.36%), α-pinene (6.75%), 1,8-cineole (5.54%) and cis-sabinene hydrate (5.29%). The T. algeriensis essential oil was found to possess an interesting inhibitory activity towards ACE with an IC50 value of 150 μg/ml. The obtained results also showed that this oil can act as radical scavengers (IC50=0.8mg/ml) and displayed a lipid peroxidation inhibitory activity (IC50=0.5mg/ml) as evaluated by 2,2-diphenyl-1-piciylhydrazyl and β-carotene bleaching methods, respectively. Furthermore, the oil was tested for antimicrobial activity against six bacterial strains and two fungal strains. The inhibition zones and minimal inhibitory concentration values of microbial strains were in the range of 13.5-64mm and 1-6 μl/ml, respectively. The oil exhibited remarkable inhibitory activity against fungal and Gram-positive bacteria strains.
- Subjects
CHEMICAL inhibitors; ANGIOTENSIN converting enzyme; ESSENTIAL oils; PEROXIDATION; GRAM-positive bacteria; ANTI-infective agents
- Publication
Food & Bioproducts Processing: Transactions of the Institution of Chemical Engineers Part C, 2011, Vol 89, Issue 4, p257
- ISSN
0960-3085
- Publication type
Article
- DOI
10.1016/j.fbp.2010.11.006