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- Title
Comparison between gadolinium-enhanced 2D T1-weighted gradient-echo and spin-echo sequences in the detection of active multiple sclerosis lesions on 3.0T MRI.
- Authors
Aymerich, F.; Auger, C.; Alcaide-Leon, P.; Pareto, D.; Huerga, E.; Corral, J.; Mitjana, R.; Sastre-Garriga, J.; Montalban, X.; Rovira, A.; Aymerich, F X; Corral, J F
- Abstract
<bold>Objectives: </bold>To compare the sensitivity of enhancing multiple sclerosis (MS) lesions in gadolinium-enhanced 2D T1-weighted gradient-echo (GRE) and spin-echo (SE) sequences, and to assess the influence of visual conspicuity and laterality on detection of these lesions.<bold>Methods: </bold>One hundred MS patients underwent 3.0T brain MRI including gadolinium-enhanced 2D T1-weighted GRE and SE sequences. The two sets of contrast-enhanced scans were evaluated in random fashion by three experienced readers. Lesion conspicuity was assessed by the image contrast ratio (CR) and contrast-to-noise ratio (CNR). The intracranial region was divided into four quadrants and the impact of lesion location on detection was assessed in each slice.<bold>Results: </bold>Six hundred and seven gadolinium-enhancing MS lesions were identified. GRE images were more sensitive for lesion detection (0.828) than SE images (0.767). Lesions showed a higher CR in SE than in GRE images, whereas the CNR was higher in GRE than SE. Most misclassifications occurred in the right posterior quadrant.<bold>Conclusions: </bold>The gadolinium-enhanced 2D T1-weighted GRE sequence at 3.0T MRI enables detection of enhancing MS lesions with higher sensitivity and better lesion conspicuity than 2D T1-weighted SE. Hence, we propose the use of gadolinium-enhanced GRE sequences rather than SE sequences for routine scanning of MS patients at 3.0T.<bold>Key Points: </bold>• 2D SE and GRE sequences are useful for detecting active MS lesions. • Which of these sequences is more sensitive at high field remains uncertain. • GRE sequence showed better sensitivity for detecting active MS lesions than SE. • We propose GRE sequence for detecting active MS lesions at 3.0T.
- Subjects
MULTIPLE sclerosis diagnosis; GADOLINIUM; MAGNETIC resonance imaging of the brain; BRAIN imaging; PRECANCEROUS conditions; BRAIN; COMPARATIVE studies; DIAGNOSTIC imaging; MAGNETIC resonance imaging; RESEARCH methodology; MEDICAL cooperation; MULTIPLE sclerosis; ORGANOMETALLIC compounds; RESEARCH; RESEARCH evaluation; EVALUATION research; CONTRAST media
- Publication
European Radiology, 2017, Vol 27, Issue 4, p1361
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-016-4503-3