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- Title
MRI-based biodistribution assessment of holmium-166 poly(L-lactic acid) microspheres after radioembolisation.
- Authors
Maat, Gerrit; Seevinck, Peter; Elschot, Mattijs; Smits, Maarten; Leeuw, Hendrik; Schip, Alfred; Vente, Maarten; Zonnenberg, Bernard; Jong, Hugo; Lam, Marnix; Viergever, Max; Bosch, Maurice; Nijsen, Johannes; Bakker, Chris
- Abstract
Objectives: To demonstrate the feasibility of MRI-based assessment of the intrahepatic Ho-PLLA-MS biodistribution after radioembolisation in order to estimate the absorbed radiation dose. Methods: Fifteen patients were treated with holmium-166 (Ho) poly(L-lactic acid)-loaded microspheres (Ho-PLLA-MS, mean 484 mg; range 408-593 mg) in a phase I study. Multi-echo gradient-echo MR images were acquired from which R maps were constructed. The amount of Ho-PLLA-MS in the liver was determined by using the relaxivity r of the Ho-PLLA-MS and compared with the administered amount. Quantitative single photon emission computed tomography (SPECT) was used for comparison with MRI regarding the whole liver absorbed radiation dose. Results: R maps visualised the deposition of Ho-PLLA-MS with great detail. The mean total amount of Ho-PLLA-MS detected in the liver based on MRI was 431 mg (range 236-666 mg) or 89 ± 19 % of the delivered amount (correlation coefficient r = 0.7; P < 0.01). A good correlation was found between the whole liver mean absorbed radiation dose as assessed by MRI and SPECT (correlation coefficient r = 0.927; P < 0.001). Conclusion: MRI-based dosimetry for holmium-166 radioembolisation is feasible. Biodistribution is visualised with great detail and quantitative measurements are possible. Key Points: • Radioembolisation is increasingly used for treating unresectable primary or metastatic liver tumours. • MRI-based intrahepatic microsphere biodistribution assessment is feasible after holmium-166 radioembolisation. • MRI enables quantification of holmium-166 microspheres in liver in a short imaging time. • MRI can estimate the whole liver absorbed radiation dose following holmium-166 radioembolisation.
- Subjects
FEASIBILITY studies; MAGNETIC resonance imaging; MEDICAL imaging systems; RADIATION doses; RADIATION dosimetry; LIVER tumors
- Publication
European Radiology, 2013, Vol 23, Issue 3, p827
- ISSN
0938-7994
- Publication type
Article
- DOI
10.1007/s00330-012-2648-2