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- Title
Plasma RNA viral load is not associated with intrapatient quasispecies heterogeneity in HIV-1 infection.
- Authors
Bello, G.; Casado, C.; García, S.; Rodríguez, C.; del Romero, J.; Borderia, A. V.; López-Galíndez, C.
- Abstract
The human immunodeficiency virus type 1 (HIV-1) viral set point has been associated with the rate of disease progression and with the level of HIV-specific immune response. The analysis of the possible association between viral set point and quasispecies heterogeneity has important consequences in the understanding of HIV-1in vivoevolution. In this study, we analyzed the association between intrapatient viral diversity and RNA viral load in 16 antiretroviral therapy-naïve HIV-1-infected patients at a single time point, during the disease free period. Patients were separated into low and high viral load groups according to plasma RNA values. HIV-1 quasispecies complexity was assessed in the C2-V5envregion. The average intrapatient quasispecies heterogeneity in both groups was not significantly different (t-test, P>0.05). However, while within the low viral load group both synonymous and non-synonymous mutations contribute to the variation observed, in the heterogeneity observed in the high viral load group there was an increase in the contribution of the non-synonymous mutations. Thus, this study show that although intrapatient quasispecies heterogeneity is not associated with viral set point in HIV-1 infection, some differences exist between the two groups in the pattern of mutation accumulation.
- Subjects
HIV infections; VIRAL load; HIV; IMMUNE response; VIROLOGY; ANTIRETROVIRAL agents
- Publication
Archives of Virology, 2004, Vol 149, Issue 9, p1761
- ISSN
0304-8608
- Publication type
Article
- DOI
10.1007/s00705-004-0322-y