We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
In vitro Activity of SCH-34343, a New Penam, and Other Antimicrobial Agents against Clinical Isolates from Cancer Patients.
- Authors
Rolston, Kenneth V.I.; Alvarez, Maria Elena; Hoy, Jennifer F.; Alderman, Helen C.; Ho, Dah Hsi; Bodey, Gerald P.
- Abstract
The in vitro activity of SCH-34343, a new penam antibiotic, was tested against gram-positive and gram-negative isolates from cancer patients, and compared to that of 7 other antimicrobial agents. SCH-34343 was extremely active against the Enterobacteriaceae with MIC90s ranging from 0.39 to 6.25 μg/ml for Citrobacter spp., Enterobacter spp., Escherichia coli, Klebsiella spp., Proteus spp. and Serratia marcescens. It was less active against Acinetobacter spp. (MIC90 6.25-12.5 μg/ml) and had poor activity against Pseudomonas aeruginosa. Among gram-positive isolates group A and G β-hemolytic Streptococci were extremely susceptible to SCH-34343 (MIC90 0.025-0.05 μg/ml). Good activity against methicillin-susceptible coagulase-positive and coagulase-negative Staphylococci and Listeria monocytogenes, and moderate activity against Enterococci was also seen. Copyright © 1986 S. Karger AG, Basel
- Publication
Chemotherapy (0009-3157), 1986, Vol 32, Issue 6, p506
- ISSN
0009-3157
- Publication type
Article
- DOI
10.1159/000238460