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- Title
Time to target haemoglobin concentration (11 g/dl) risk of hospitalization and mortality among incident dialysis patients.
- Authors
Areef Ishani; Haifeng Guo; David T. Gilbertson; Jiannong Liu; Stephan Dunning; Allan J. Collins; Robert N. Foley
- Abstract
Background. Haemoglobin levels Methods. We studied 29 131 patients initiating dialysis in 2002 and surviving â¥9 months. Demographic, comorbid and health care use data were extracted from Medicare claims from months 4â9 post-dialysis initiation. Logistic regression was used to calculate a propensity score for odds of longer than mean time to target. Proportional hazard models were used to assess effects of longer time on hospitalization and death. Other models were stratified for quartile of propensity score. Results. Mean time to target haemoglobin was 1.3 months and 36% of participants required longer. These were more likely to be younger and minority, to use a dialysis catheter, and to have more comorbidity and hospitalization days during the entry period. Longer time to target was associated with increased risk for hospitalization (hazards ratio 1.15; 95% confidence interval 1.12â1.19) and mortality (1.26; 1.20â1.33) in the following year. Associations did not change when stratified by quartile of propensity score. Conclusions. Longer time required to reach the target haemoglobin level was associated with significantly higher risk of hospitalization and mortality. Whether observed associations resulted from residual confounding by more severe illness remains unclear. Future trials should determine if rapidity of haemoglobin correction influences outcomes.
- Subjects
HEALTH risk assessment; HEMODIALYSIS patients; MORTALITY; HOSPITAL care
- Publication
Nephrology Dialysis Transplantation, 2007, Vol 22, Issue 8, p2247
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/gfm374