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- Title
The effect of pH and nucleophiles on complement activation by human proximal tubular epithelial cells.
- Authors
Peake, Philip W.; Pussell, Bruce A.; Mackinnon, Bruce; Charlesworth, John A.
- Abstract
Background. Activation of urinary complement proteins in situ by proximal tubular epithelial cells (PTEC) may contribute to the mediation of tubulointerstitial injury in patients with significant proteinuria. However, the mechanism involved is unclear, and the role of changes in urinary pH and in the concentrations of urea or ammonia requires further clarification.
- Publication
Nephrology Dialysis Transplantation, 2002, Vol 17, Issue 5, p745
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/17.5.745