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- Title
Influence of dialyser clearance measurement accuracy on haemodialysis prescription based onKt/V.
- Authors
Zehnder, C.; Blumberg, A.
- Abstract
/ urea (u) has been used as a measure of adequacy of haemodialysis (HD). However, the accurate assessment of its components is difficult and subject to error in a clinical setting. This study was designed to evaluate different forms of dialyser clearance () measurements and their influence on . Sixteen patients on high-flux HD were studied at blood flow () rates of 250 and 350 ml/min and at constant dialysate flow rates. of urea was measured by the arteriovenous blood sampling technique (), corrected for access recirculation () and compared with as determined by dialysate collection () using a new sampling device. At 250 and 350 ml/min, as based on dialysate collection was significantly lower than and as based on arteriovenous blood sampling: at 250, 169.0± 13.3, 191.2±11.5, and 203.0±9.3 ml/min (P<0.0005); at 350, 196.5±17.3, 227.7±15.5, and 243.6±12.7 ml/min (<0.0005). At 250 ml/min (1.33±0.17) overestimated (1.11±0.13) by 16.8%, at 350 ml/min by 19.3% (1.58 ± 0.19 versus 1.27±0.15). Dialyser clearances based on arteriovenous differences in blood overestimate true clearances (and therefore ) as measured by dialysate collection. This overestimation is more marked with higher blood flow rates.
- Publication
Nephrology Dialysis Transplantation, 1994, Vol 9, Issue 7, p753
- ISSN
0931-0509
- Publication type
Article