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- Title
Antimicrobial resistance in Haemophilus influenzae from England and Scotland in 1991.
- Authors
Powell, M.; Fah, Y. S.; Seymour, A.; Yuan, M.; Williams, J. D.; Yeo, S F
- Abstract
Twenty-two laboratories in England and Scotland sent 2212 clinical isolates of Haemophilus influenzae to The London Hospital Medical College (LHMC) between 1 January and 31 March 1991. After confirmation of identity, the prevalence of resistance was determined and compared with results from previous similar surveys. beta-Lactamase was produced by 8.3% of non-capsulate isolates and 21% of 52 type b isolates; both figures were higher than the 6% and 18% figures recorded, respectively, in 1986. There was an increase in the prevalence of non-beta-lactamase-mediated diminished susceptibility to ampicillin (5.8%) and co-amoxiclav (6.1%) compared with 1986 (4%). Whereas fewer H. influenzae isolates were resistant to tetracycline (1.4%) or chloramphenicol (0.8%), there was an increase in resistance to trimethoprim (6.8%) and to sulphamethoxazole (16.9%) compared with 1986 (4.2% and 3.5% respectively). In addition, 95 isolates (4.3%) were resistant to both of these anti-folate antimicrobials. Six isolates (one type b from CSF) were resistant to all drugs tested, except for co-amoxiclav. Overall, the results demonstrated that changes have occurred in the last decade in England and Scotland, such that H. influenzae isolates are increasingly likely to be resistant to ampicillin, co-amoxiclav and co-trimoxazole.
- Subjects
COMPARATIVE studies; DRUG resistance in microorganisms; HAEMOPHILUS influenzae; HYDROLASES; RESEARCH methodology; MEDICAL cooperation; MICROBIAL sensitivity tests; RESEARCH; RESPIRATORY infections; SULFAMETHOXAZOLE; EVALUATION research; PHARMACODYNAMICS
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1992, Vol 29, Issue 5, p547
- ISSN
0305-7453
- Publication type
journal article