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- Title
The penetration of roxithromycin into human skin.
- Authors
Campa, M.; Zolfino, I.; Senesi, S.; Bernardini, N.; Danesi, R.; Ducci, M.; Oleggini, M.; Di Stefano, R.; Mosca, F.; Lazzarini, A.; Del Tacca, M.
- Abstract
The skin penetration of roxithromycin was studied in 27 surgical patients treated with 300 mg orally followed by three oral doses of 150 mg 12-hourly. Peak plasma and skin concentrations of 7.9±1.2 mg/l and 31.3±3.7 mg/kg occurred 2.5 and 4 h after last dosing respectively. The plasma and skin half-lives were 7.7 and 6.0 h, and the mean plasma and skin area under the curve values were 64.3 mg/l.h and 155.3 mg/kg.h. Skin/plasma concentration ratios were 4.9±0.5, 9.7±1.2, 7.6±0.8 and 5.9±1.1, at 3, 4, 5 and 6 h after last dosing respectively. These results demonstrate that roxithromycin achieves high levels in human skin.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1990, Vol 26, Issue 1, p87
- ISSN
0305-7453
- Publication type
journal article