We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The penetration of ceftriaxone into synovial fluid of the inflamed joint.
- Authors
Morgan, John R.; Paull, Alan; O'Sullivan, Margaret; Williams, Brian D.; Morgan, J R; Paull, A; O'Sullivan, M; Williams, B D
- Abstract
Fifteen patients with acute exacerbation of rheumatoid arthritis each received a 1 g bolus intravenous injection of ceftriaxone. Serum and synovial fluid was sampled at intervals between 1 h and 24 h later and assayed for ceftriaxone. Synovial fluid leucocyte counts and albumin content were measured concomitantly. Detectable levels of ceftriaxone were found in synovial fluid and serum 24 h after injection. Synovial fluid ceftriaxone concentration ranged between 66% and 100% of the concomitant serum levels. No correlation was observed between synovial fluid ceftriaxone concentration and synovial fluid leucocyte count and albumin concentration.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1985, Vol 16, Issue 3, p367
- ISSN
0305-7453
- Publication type
journal article