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- Title
Planning your route from the start.
- Authors
Leavy, Olive
- Abstract
The article highlights the study, "Distinct pathways of antigen uptake and intracellular routing in CD4 and CD8 T cell activation," by S. Burgdorf, previously published in a 2007 issue of the periodical "Science." Results reveal that antigen-presenting cells use distinct methods of endocytosis to simultaneously direct extracellular antigen into specific intracellular compartments, and that these compartments then dictate whether the antigen is presented to CD4+ or CD8+ T cells.
- Subjects
CD antigens; T cells; ENDOCYTOSIS; CELL surface antigens; FC receptors; GLYCOPROTEINS
- Publication
Nature Reviews Immunology, 2007, Vol 7, Issue 6, p416
- ISSN
1474-1733
- Publication type
Article
- DOI
10.1038/nri2107