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- Title
Non-Coding RNA-Dependent Regulation of Mitochondrial Dynamics in Cancer Pathophysiology.
- Authors
Gallo Cantafio, Maria Eugenia; Torcasio, Roberta; Viglietto, Giuseppe; Amodio, Nicola
- Abstract
Mitochondria are essential organelles which dynamically change their shape and number to adapt to various environmental signals in diverse physio-pathological contexts. Mitochondrial dynamics refers to the delicate balance between mitochondrial fission (or fragmentation) and fusion, that plays a pivotal role in maintaining mitochondrial homeostasis and quality control, impinging on other mitochondrial processes such as metabolism, apoptosis, mitophagy, and autophagy. In this review, we will discuss how dysregulated mitochondrial dynamics can affect different cancer hallmarks, significantly impacting tumor growth, survival, invasion, and chemoresistance. Special emphasis will be given to emerging non-coding RNA molecules targeting the main fusion/fission effectors, acting as novel relevant upstream regulators of the mitochondrial dynamics rheostat in a wide range of tumors.
- Subjects
HOMEOSTASIS; PLANT mitochondria; PATHOLOGICAL physiology; MITOCHONDRIA; NON-coding RNA; LINCRNA
- Publication
Non-Coding RNA, 2023, Vol 9, Issue 1, p16
- ISSN
2311-553X
- Publication type
Article
- DOI
10.3390/ncrna9010016