We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
On the Feedback Between Theory and Experiment in Elucidating the Molecular Mechanisms Underlying Neurotransmitter Release.
- Authors
Khanin, Raya; Parnas, Itzchak; Parnas, Hanna
- Abstract
This review describes the development of the molecular level Ca2+-voltage hypothesis. Theoretical considerations and feedback between theory and experiments played a key role in its development. The theory, backed by experiments, states that at fast synapses, membrane potential by means of presynaptic inhibitory autoreceptors controls initiation and termination of neurotransmitter release. A molecular kinetic scheme which depicts initiation and termination of evoked release is discussed. This scheme is able to account for both spontaneous release and evoked release. The physiological implications of this scheme are enumerated.
- Subjects
AUTORECEPTORS; PRESYNAPTIC receptors; NEUROTRANSMITTERS; MATHEMATICAL models; SYNAPSES; NEURAL transmission
- Publication
Bulletin of Mathematical Biology, 2006, Vol 68, Issue 5, p997
- ISSN
0092-8240
- Publication type
Article
- DOI
10.1007/s11538-006-9099-3