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- Title
EVALUATION OF THE ACUTE AND SUB-ACUTE ANTI-INFLAMMATORY PROPERTY OF THE AQUEOUS STEM BARK EXTRACT OF PARKIA FILICOIDEA WELW (FABACEAE).
- Authors
NKWERE, C.; AKHIGBEMEN, A. M.; BOLANLE, I. O.; ARHEWOH, M. I.; OWOLABI, O. J.
- Abstract
Parkia filicoidea, Welw (Fabecea) plant parts are claimed to be used as herbal medicine in the management of inflammation. This claim however has not been substantiated, scientifically, hence the need for this study. The powdered stem bark of Parkia filocoidea was extracted by hot aqueous decoction, cooled and strained. Oral acute toxicity study was carried out in rats using Lorke’s method. Test doses of 100, 200 and 400 mg/kg of the extract were evaluated for antiinflammatory activity using Carrageenan- induced paw edema, dextran- induced paw edema and formalin- induced paw edema models of inflammation studies in albino rats. Indomethacin (10 mg/kg) and distilled water (2 ml/kg) were used as the positive and negative controls respectively. The oral acute toxicity study revealed no mortality or signs of toxicity in both phases of the study, even after 14 days. Doses of 100, 200 and 400 mg/kg of Parkia filocoidea extract produced significant (p<0.05) anti-inflammatory properties in the acute inflammatory models (carrageenan- and dextraninduced paw edema) but had no significant inhibitory effect in the sub-acute inflammatory model (formalin-induced paw edema) in rats when compared with the control. The effect of the extract is comparable to indomethacin in the acute models. The result is in tandem with the claim of the ethno medical use of the extract of Parkia filicoidea in the treatment of inflammatory conditions.
- Subjects
ACUTE toxicity testing; EXPERIMENTAL arthritis; LEGUMES; HERBAL medicine; DISTILLED water
- Publication
Journal of Pharmaceutical & Allied Sciences, 2023, Vol 20, Issue 1, p3843
- ISSN
1596-8499
- Publication type
Article