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- Title
Association of Plasma Small-Molecule Intermediate Metabolites With Age and Body Mass Index Across Six Diverse Study Populations.
- Authors
Kraus, William E.; Pieper, Carl F.; Huffman, Kim M.; Thompson, Dana K.; Kraus, Virginia B.; Morey, Miriam C.; Cohen, Harvey J.; Ravussin, Eric; Redman, Leanne M.; Bain, James R.; Stevens, Robert D.; Newgard, Christopher B.
- Abstract
<bold>Background: </bold>Older age and obesity are associated with metabolic dysregulation; the mechanism by which these factors impact metabolism across the lifespan is important, but relatively unknown. We evaluated a panel of amino acids (AAs) and acylcarnitines (ACs) to identify effects of age and adiposity (body mass index) on circulating small-molecule metabolites in a meta-analysis of six diverse study populations.<bold>Methods: </bold>Targeted metabolic profiling was performed in six independent studies, representing 739 subjects with a broad range of age, body mass index, health states, and ethnic origin. Principal components analysis was performed on log-normalized values for AAs and ACs separately, generating one AC factor and two AA factors for each study. A common AC factor consisted primarily of acetylcarnitine, medium-chain AC, and several long-chain AC. AA Factor 1 consisted primarily of large neutral AAs. Glycine was its own factor.<bold>Results: </bold>Metabolic profiling and factor analysis identified clusters of related metabolites of lipid and AA metabolism that were consistently associated with age and body mass in a series of studies with a broad range of age, body mass index, and health status. An inverse association of glycine with body mass index and male gender supports its role as a marker of favorable metabolic health.<bold>Conclusions: </bold>An important focus of future investigations should be to determine whether these clusters of metabolic intermediates are possible early predictors of health outcomes associated with body mass; are involved with accelerated aging; are involved in the causative pathway of aging; and how modification of these metabolic pathways impact the biology of aging.
- Subjects
ELDER care; OBESITY; METABOLIC disorders; AMINO acids; BODY mass index; AMINO acid metabolism; AGING; BIOCHEMISTRY; BLOOD plasma; CARNITINE; META-analysis
- Publication
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2016, Vol 71, Issue 11, p1507
- ISSN
1079-5006
- Publication type
journal article
- DOI
10.1093/gerona/glw031