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- Title
乳腺导管原位癌和浸润性导管癌中 MMP-7、VEGF 及 E-cad 的表达及临床意义.
- Authors
刘国军; 吴小蔚; 孙圣荣; 毛哲玉; 张书卿
- Abstract
Objective: To investigate the expressions and clinical significance of Matrix metalloproteinase -7 (MMP-7), vascular endothelial growth factor (VEGF) and Calcium adherent E (E<ad) in breast ductal carcinoma in situ (DCIS) and invasive ductal carcinoma(IDC). Methods: 59 cases of DCIS paraffin embedded specimens {DCIS group). 32 cases of IDC' paraffin embedded specimens (IDC' group) in Hubei Medical Group of breast and thyroid surgery of Huangshi Central Hospital from January 2012 to August 2017 were selected. 20 cases of normal breast tissue samples during the same period were selected as control group. The expressions of MMP-7, VEGF and E-cad in each group were detected. The relationship between the positive expression rates of MMP-7. VEGF and E-cad and the clinic opathological features of patients with DCIS and EDC were analyzed. The correlation between MMP-7, VEGF and E-cad were analyzed by Pearson correlation. Results: The positive expression rates of MMP-7 and VEGF in DCIS group and IDC group were higher than those in the control group, the strong positive expression rate of E-cad was lower than that in the control group (P<0.05); mere was no significant difference in the positive expression rate of MMP-7. \*EGF and E-cad between DCIS group and IDC group (PKI.05). The positive rates of MMP-7, VEGF and E-cad were not related to the age of the patients and the size of the tumor (P>0.05). The positive expression rates of MMP-7 and VEGF in the patients with II-IH stage, intermediate I low degree of differentiation and lymph node metastasis were higher than those of the patients with I stage, high differentiation degree and no lymph node metastasis (P<0.05). The positive rate of E-cad in patients with moderate / low differentiation and lymph node metastasis was lower than those of patients with high differentiation and no lymph node metastasis (P<0.05). Pearson correlation analysis showed mat there was a positive correlation between MMP-7 and VEGF(r=0.362, P=0.038), MMP-7 and VEGF were not significantly correlated with E-cad (r=0.071,0.024, P=0.057, 0.089). Conclusion: The expressions of MMP-7 and VEGF in DCIS group and IDC group are higher, but the expression of E-cad is lower, which is related to the clinical stage, degree of differentiation and lymph node metastasis of the patients. The development of breast cancer can be evaluated by examining the expressions of MMP-7, VEGF and E-cad.
- Publication
Progress in Modern Biomedicine, 2018, Vol 18, Issue 10, p1897
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2018.10.018