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- Title
α-硫辛酸对糖尿病肾病患者氧化应激, Hcy, CysC 的影响.
- Authors
奚敏慧; 赵歆辉; 朱爱国; 徐佳; 陆璟园
- Abstract
Objective: To investigate the effect of α-lipoic acid on oxidative stress, Hcy and CysC in the patients with diabetic nephropathy. 82 patients with type 2 diabetic nephropathy were divided into control group (41 cases) and observation group (41 cases). The patients in two groups were given the conventional therapy, and the patients in observation group were received extra α-lipoic acid, they were all treated for 2 weeks. The treatment effects were observed and the levels of oxidative stress indexes (SOD and MDA), Hcy and CysC were tested and compared. After treatment, the level of SOD was increased significantly, the level of MDA was decreased significantly in observation group (P<0.05), the levels of SOD and MDA had no significant difference before and after treatment in control group (P>0.05), but the levels of SOD and MDA had significant difference after treatment in two groups(P<0.05); After treatment, the levels of Hcy and CysC were decreased significantly in observation group (P<0.05), the levels of Hcy and CysC had no significant difference before and after treatment in control group (P>0.05), but the levels of Hcy and CysC had significant difference after treatment in two groups (P<0.05). α-lipoic acid can alleviate oxidative stress, reduce Hcy, CysC levels and improve renal function in patients with diabetic nephropathy.
- Publication
Progress in Modern Biomedicine, 2017, Vol 17, Issue 8, p1457
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2017.08.012