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- Title
The effects of capsinoids and fermented red pepper paste supplementation on Glycaemic Control: A systematic review and meta‐analysis of randomised controlled trials.
- Authors
Amini, Mohammad Reza; Talebyan, Alireza; Payandeh, Nastaran; Sheikhhossein, Fatemeh; Mohtashaminia, Fatemeh; Gholami, Fatemeh
- Abstract
Objective: The present systematic review and meta‐analysis were conducted to investigate the effects of capsinoids supplementation on glycaemic control. Methods: Relevant studies, published up to May 2020, were searched through PubMed/Medline, Scopus, ISI Web of Science, Embase and Google Scholar. All randomised clinical trials investigating the effect of capsinoids supplementation on glycaemic control were included. Results: Of 326 citations, eight trials with nine effect sizes that enrolled 530 subjects were included. Capsinoids and red pepper resulted in no significant reduction in glucose (Weighted mean differences (WMD): −0.27 mg/dL; 95% CI: −1.9 to 1.37, P =.75), insulin (WMD: −0.09 µU/mL; 95% CI: −1.76 to 1.57, P =.913), homeostatic model assessment for insulin resistance (HOMA‐IR) (WMD: 0.52; 95% CI: −0.29 to 1.32, P =.208) and haemoglobin A1C (HbA1C) (WMD: 0.01%; 95% CI: −0.04 to 0.05, P =.712). Greater effects on glucose were detected in trials performed on both gender, using red pepper, lasted ≥12 weeks, and participants aged >40 years old and recruited greater sample size >50. Insulin and HOMA‐IR were reduced by using red pepper. Conclusion: Overall, these data suggest that capsinoids and red pepper supplementation did not have beneficial effects on glucose, insulin, HbA1C and HOMA‐IR but significantly reduce glucose in people older than 40 years.
- Publication
International Journal of Clinical Practice, 2021, Vol 75, Issue 12, p1
- ISSN
1368-5031
- Publication type
Article
- DOI
10.1111/ijcp.14803