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- Title
Assessment of bone quality with trabecular bone score in type 2 diabetes mellitus: A study from the FRISBEE cohort.
- Authors
Baleanu, Felicia; Bergmann, Pierre; Hambye, Anne Sophie; Dekelver, Carole; Iconaru, Laura; Cappelle, Sylvie I.; Moreau, Michel; Paesmans, Marianne; Karmali, Rafik; Body, Jean‐Jacques; Body, Jean-Jacques
- Abstract
<bold>Objective: </bold>The purpose of our study was to compare bone mineral density (BMD) and trabecular bone score (TBS) values between patients with type 2 diabetes (T2D) and control subjects with similar FRAX scores in order to evaluate TBS as an additional tool for assessing fracture risk in diabetic subjects.<bold>Methods: </bold>A cross-sectional analysis was performed using BMD results from 260 subjects participating in the FRISBEE study (Fracture RISk Brussels Epidemiological Enquiry), an ongoing prospective epidemiological study in a population-based cohort (Brussels, Belgium) of 3560 postmenopausal women aged 60-85 years. TBS measurement was possible in 1108 subjects from the FRISBEE cohort. Among these 1108 subjects, 65 had known T2D at inclusion. For each diabetic case we selected 3 controls from our database. (n = 195). Diabetic subjects and controls were matched for age and baseline FRAX score for major osteoporotic fractures.<bold>Results: </bold>BMD (g/cm2 ) tended to be higher in T2D than in control subjects, significantly so at the total hip 0.90 ± 0.13 versus 0.87 ± 0.12 (P = 0.015). On the contrary, TBS was significantly lower in the T2D group (mean = 1.19 ± 0.17) compared with the control group (mean = 1.27 ± 0.13) (P = 0.005). Mean TBS remained significantly lower in T2D (1.22 ± 0.17) compared with the control group (1.27 ± 0.13) (P = 0.02) after adjustment for body mass index.<bold>Conclusion: </bold>Our data suggest that TBS complements BMD at the total hip, in demonstrating the "diabetes-associated bone disease".
- Publication
International Journal of Clinical Practice, 2019, Vol 73, Issue 5, pN.PAG
- ISSN
1368-5031
- Publication type
journal article
- DOI
10.1111/ijcp.13347