We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Synthesis, biological evaluation, and molecular docking studies of diacylhydrazine derivatives possessing 1,4-benzodioxan moiety as potential anticancer agents.
- Authors
Wang, S.; Liu, H.-Y.; Xu, R.-F.; Sun, J.
- Abstract
A series of diacylhydrazine derivatives containing 1,4-benzodioxan 1-17 has been designed, synthesized and evaluated for antitumor activity. Most of the synthesized compounds demonstrated potent antitumor activity and low toxicity. Compound 10 demonstrated the most potent biological activity against MCF-7 cancer cell line, which was comparable with the positive control 5-fluorouracil. Docking simulation by positioning compound 10 into the MetAP2 structure active site was performed to explore the possible binding model.
- Subjects
MOLECULAR docking; ANTINEOPLASTIC agents; CHEMICAL derivatives; FUNCTIONAL groups; CHEMICAL synthesis; CELL lines
- Publication
Russian Journal of General Chemistry, 2017, Vol 87, Issue 11, p2671
- ISSN
1070-3632
- Publication type
Article
- DOI
10.1134/S1070363217110238