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- Title
Role of nasal positive end expiratory pressure valve as an alternative treatment for obstructive sleep apnoea in Chinese patients.
- Authors
To, Kin Wang; Chan, Tat O.; Ng, Susana; Ngai, Jenny; Hui, David SC.
- Abstract
Background and objective As compliance of continuous positive airway pressure ( CPAP) for treatment of obstructive sleep apnoea ( OSA) is often suboptimal, a less cumbersome treatment is desirable. We explored the clinical usefulness of nasal positive end expiratory pressure (n PEEP) valves. Methods Symptomatic OSA patients (apnoea hypopnea index ( AHI) >5/h by polysomnography ( PSG) or >10/h by type III devices), who declined CPAP, were recruited. A nPEEP valve was attached to each nostril before bed. After successful acclimatization for 1 week, treatment was continued for 4 weeks. The n PEEP valves provided expiratory resistance to build up PEEP. PSG was performed at week 4. Results Among 196 subjects, 46 (23%) failed acclimatization and 14 (7%) withdrew. Among the 120 patients with a valid PSG, 72 (60%) and 75 (63%) had >50% reduction in mean (standard deviation) overall AHI 26 (16)/h to 18 (18)/h and mean supine AHI 31 (19)/h to 11(16)/h, respectively, P < 0.001. Compared with responders, patients with <50% reduction in AHI had a higher mean overall AHI (30/h vs 23/h, P = 0.03), higher mean supine AHI (35/h vs 26/h, P = 0.04), more severe mean oxygen desaturation nadir (76.7% vs 82.7%, P < 0.01) and longer mean period of desaturation <90% SaO2 (7.7 vs 2.4, P = 0.02). Breathing discomfort and dry mouth were the most common side effects. Compared with a dental device, there was a larger mean reduction in supine AHI using n PEEP (29 (14)/h vs 16 (17)/h). Conclusion nPEEP valves were useful in selected patients with mild or positional-related OSA.
- Subjects
EXPIRATORY flow; SLEEP apnea syndromes; POLYSOMNOGRAPHY; RESPIRATION; DENTAL equipment
- Publication
Respirology, 2016, Vol 21, Issue 3, p541
- ISSN
1323-7799
- Publication type
Article
- DOI
10.1111/resp.12703