We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Study of gastro-oesophageal reflux disease in patients with mild-to-moderate chronic obstructive pulmonary disease in India.
- Authors
KAMBLE, NITISH L.; KHAN, NAUSHAD A.; KUMAR, NARESH; NAYAK, HEMANTA K.; DAGA, MRADUL K.
- Abstract
ABSTRACT Background and objective: To study the incidence and pattern of gastro-oesophageal reflux disease (GORD) in patients with mild-to-moderate chronic obstructive pulmonary disease (COPD) using dual-probe 24-h oesophageal pH recording. Methods: This was a prospective study of 50 patients with mild-to-moderate stage COPD based on the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines. A detailed history of illness along with spirometry was done in all patients. In the study group, reflux symptoms were measured using a validated scoring system. All the patients underwent oesophageal manometry and dual-probe 24-h oesophageal pH recording. Results: Symptoms of gastro-oesophageal reflux were present in 38 patients. Twenty-four-hour oesophageal pH monitoring revealed pathological reflux in 31 out of 38 symptomatic and 8 out of 12 asymptomatic patients. The overall rate of GORD was 78% in our study. Only distal GORD was observed in 11 (28.9%), and both distal and proximal GORD was observed in 20 (52.6%) out of the 38 symptomatic subjects. In the remaining 12 asymptomatic patients, eight had GORD. Distal GORD was present in six (50%) patients, and two (16.6%) had both distal and proximal GORD in this group. Isolated proximal GORD was not observed in any patient. Conclusions: There is an increased occurrence of GORD in patients with even mild-to-moderate COPD.
- Subjects
INDIA; GASTROESOPHAGEAL reflux; OBSTRUCTIVE lung diseases patients; HYDROGEN-ion concentration measurement; SYMPTOMS; DISEASE prevalence
- Publication
Respirology, 2013, Vol 18, Issue 3, p463
- ISSN
1323-7799
- Publication type
Article
- DOI
10.1111/j.1440-1843.2012.02285.x