We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
A New Strategy to Deliver Synthetic Protein Drugs: Self-reproducible Biologics Using Minicircles.
- Authors
Hyoju Yi; Youngkyun Kim; Juryun Kim; Hyerin Jung; Rim, Yeri Alice; Seung Min Jung; Sung-Hwan Park; Ji Hyeon Ju
- Abstract
Biologics are the most successful drugs used in anticytokine therapy. However, they remain partially unsuccessful because of the elevated cost of their synthesis and purification. Development of novel biologics has also been hampered by the high cost. Biologics are made of protein components; thus, theoretically, they can be produced in vivo. Here we tried to invent a novel strategy to allow the production of synthetic drugs in vivo by the host itself. The recombinant minicircles encoding etanercept or tocilizumab, which are synthesized currently by pharmaceutical companies, were injected intravenously into animal models. Self-reproduced etanercept and tocilizumab were detected in the serum of mice. Moreover, arthritis subsided in mice that were injected with minicircle vectors carrying biologics. Self-reproducible biologics need neither factory facilities for drug production nor clinical processes, such as frequent drug injection. Although this novel strategy is in its very early conceptual stage, it seems to represent a potential alternative method for the delivery of biologics.
- Subjects
PROTEIN drugs; SYNTHETIC proteins; SYNTHETIC enzymes; BIOLOGICALS; BIOLOGICAL products
- Publication
Scientific Reports, 2014, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/srep05961