We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Outcome of High-Dose Chemotherapy Followed by Autologous Stem Cell Transplantation in Relapsed/Refractory Hodgkin Lymphoma after Different Numbers of Salvage Regimens.
- Authors
Mariotti, Jacopo; Ricci, Francesca; Giordano, Laura; Taurino, Daniela; Sarina, Barbara; De Philippis, Chiara; Mannina, Daniele; Carlo-Stella, Carmelo; Bramanti, Stefania; Santoro, Armando
- Abstract
The introduction of novel drugs (PD-1 inhibitors and/or brentuximab vedotin) into salvage regimens has improved the response rate and the outcome of patients with relapsed/refractory Hodgkin lymphoma. However, the impact of new drugs on the outcome has not been adequately investigated so far. We retrospectively analyzed 42 consecutive patients treated at our institution with high-dose chemotherapy/autologous stem cell transplantation after either one standard chemotherapy represented by BEGEV (n = 28) or >1 salvage therapy (ST) comprising novel drugs (n = 14). With a median follow-up of 24 months, the 2-year cumulative incidence of relapse was similar between the two cohorts: 26% for 1 ST and 18% for >1 ST (p = 0.822). Consistently, overall survival and progression-free survival did not differ among the two groups: 3-year overall survival was 91% and 89% (p = 0.731), respectively, and 3-year progression-free survival was 74% and 83% (p = 0.822) for only one and more than one salvage regimens, respectively. Of note, the post-transplant side effects and engraftment rates were similar between the 1 ST and >1 ST cohorts. In conclusion, consolidation with high-dose chemotherapy/autologous stem cell transplantation is a safe and curative option, even for patients achieving disease response after more than one rescue line of therapy.
- Subjects
STEM cell transplantation; HODGKIN'S disease; PROGRESSION-free survival; CONSOLIDATION chemotherapy; SALVAGE therapy
- Publication
Cells (2073-4409), 2024, Vol 13, Issue 2, p118
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells13020118