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- Title
The Research Progress in Transforming Growth Factor-β2.
- Authors
Wang, Meng-Yan; Liu, Wen-Juan; Wu, Le-Yi; Wang, Gang; Zhang, Cheng-Lin; Liu, Jie
- Abstract
Transforming growth factor-beta 2 (TGF-β2), an important member of the TGF-β family, is a secreted protein that is involved in many biological processes, such as cell growth, proliferation, migration, and differentiation. TGF-β2 had been thought to be functionally identical to TGF-β1; however, an increasing number of recent studies uncovered the distinctive features of TGF-β2 in terms of its expression, activation, and biological functions. Mice deficient in TGF-β2 showed remarkable developmental abnormalities in multiple organs, especially the cardiovascular system. Dysregulation of TGF-β2 signalling was associated with tumorigenesis, eye diseases, cardiovascular diseases, immune disorders, as well as motor system diseases. Here, we provide a comprehensive review of the research progress in TGF-β2 to support further research on TGF-β2.
- Subjects
LITERATURE reviews; HUMAN abnormalities; CARDIOVASCULAR system; EYE diseases; IMMUNOLOGIC diseases; WNT signal transduction
- Publication
Cells (2073-4409), 2023, Vol 12, Issue 23, p2739
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells12232739