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- Title
Immunotherapy: Recent Advances and Its Future as a Neoadjuvant, Adjuvant, and Primary Treatment in Colorectal Cancer.
- Authors
Yu, Irene; Dakwar, Anthony; Takabe, Kazuaki
- Abstract
Immunotherapy in colorectal cancer (CRC) has made great strides within the past decade. Immune checkpoint inhibitors are a class of immunotherapy and have been shown to greatly improve patient outcomes in mismatch repair-deficient (dMMR) CRC. Now, they are part of the standard of care for this subset of CRC. Because of this, there has been a growing interest in the efficacy and timing of immunotherapy for other subsets of CRC, including locally advanced, metastatic, and microsatellite stable (MSS). In this review, we aim to examine the three main classes of immunotherapy for CRC—immune checkpoint inhibitors (ICIs), adoptive cell transfer therapy (ACT), and tumor vaccines—and discuss the most recent advances and future directions for each.
- Subjects
IMMUNE checkpoint inhibitors; COLORECTAL cancer; CANCER treatment; IMMUNOTHERAPY; CANCER vaccines
- Publication
Cells (2073-4409), 2023, Vol 12, Issue 2, p258
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells12020258