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- Title
Stiff-Leg Syndrome Associated with Autoimmune Retinopathy and Its Treatment with IVIg—A Case Report and Review of the Literature.
- Authors
Papadopoulos, Vassilis E.; Papadimas, George K.; Androudi, Sofia; Anagnostouli, Maria; Evangelopoulos, Maria-Eleftheria
- Abstract
Antibodies to glutamic acid decarboxylase (GAD) have been predominantly associated with stiff-person syndrome (SPS), which is often accompanied by organ-specific autoimmune diseases, such as late-onset type 1 diabetes. Autoimmune retinal pathology in SPS has recently been suggested to coexist in patients suffering from this disease; however, evidence reporting potential treatment options for the neurological and visual symptoms these patients experience remains scarce. We provide a review of the relevant literature, presenting a rare case of a middle-aged woman with autoimmune retinopathy (AIR) followed by stiff-leg syndrome who responded to intravenous immune globulin treatment (IVIg). Our report adds to previously reported data supporting the efficacy of IVIg in SPS spectrum disorders while also proposing the potential effect of IVIg in treating SPS spectrum patients with coexisting AIR.
- Subjects
LITERATURE reviews; INTRAVENOUS immunoglobulins; GLUTAMATE decarboxylase; STIFF-person syndrome; TYPE 1 diabetes; AUTOIMMUNE diseases
- Publication
Brain Sciences (2076-3425), 2023, Vol 13, Issue 10, p1361
- ISSN
2076-3425
- Publication type
Article
- DOI
10.3390/brainsci13101361