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- Title
Association between KCNQ1 genetic variants and QT interval in a Chinese population.
- Authors
Yu, W.; Zhang, F.; Hu, W.; Zhang, R.; Wang, C.; Lu, J.; Jiang, F.; Tang, S.; Peng, D.; Chen, M.; Bao, Y.; Xiang, K.; Hu, C.; Jia, W.
- Abstract
Aim There is a close link between electrocardiographic ventricular repolarization QT parameters and Type 2 diabetes. The aim of the present study was to assess the effects of QT-related and diabetes-related variants in KCNQ1 on QT interval in a Chinese population. Methods We recruited 2415 patients with Type 2 diabetes and 1163 subjects with normal glucose regulation in the present study. QT interval was obtained and the heart rate-corrected QT interval ( QTc) was calculated using Bazett's formula. Four single nucleotide polymorphisms in KCNQ1 were selected (rs12296050, rs12576239, rs2237892 and rs2237895) and genotyped. Results In participants with normal glucose regulation, the minor allele T of rs12296050 was associated with a 3.46-ms QTc prolongation under an additive model ( P = 0.0109, empirical P = 0.0498). In patients with Type 2 diabetes, we did not find any association for the single nucleotide polymorphisms. Conclusions Our findings indicate that KCNQ1 is associated with QT interval in a Chinese population with normal glucose regulation.
- Subjects
CHINA; DIABETES complications; GENETICS of diabetes; HEART ventricles; TYPE 2 diabetes diagnosis; BLOOD pressure; BLOOD pressure measurement; ELECTROCARDIOGRAPHY; GENES; GENETICS; GLYCOSYLATED hemoglobin; DATA analysis; BODY mass index; HUMAN research subjects; PATIENT selection; DATA analysis software; PHYSIOLOGY
- Publication
Diabetic Medicine, 2013, Vol 30, Issue 10, p1225
- ISSN
0742-3071
- Publication type
Article
- DOI
10.1111/dme.12237