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- Title
Cut-off values of fasting and post-load plasma glucose and HbA<sub>1c</sub> for predicting Type 2 diabetes in community-dwelling Japanese subjects: the Hisayama Study.
- Authors
Mukai, N.; Doi, Y.; Ninomiya, T.; Hata, J.; Hirakawa, Y.; Fukuhara, M.; Iwase, M.; Kiyohara, Y.
- Abstract
Diabet. Med. 29, 99-106 (2012) Abstract Aims We examined the optimal cut-off values of fasting plasma glucose, 2-h post-load glucose and HbA1c for predicting Type 2 diabetes in community-dwelling Japanese subjects. Methods A total of 1982 subjects without diabetes aged 40-79 years who underwent a 75-g oral glucose tolerance test were followed prospectively for 14 years by annual health examination. Results During the follow-up, 295 subjects developed Type 2 diabetes. Compared with the first decile, the crude hazard ratio for incident Type 2 diabetes was significantly higher in the fifth fasting plasma glucose decile [5.4-5.4 mmol/l (97-98 mg/dl)] or higher, in the seventh 2-h post-load glucose decile [6.9-7.2 mmol/l (124-131 mg/dl)] or higher, and in the fifth HbA1c decile [34-36 mmol/mol (5.3-5.4%)] or higher. These associations remained substantially unchanged even after adjustment for confounding factors. The receiver operating characteristic curve analysis showed that the optimal cut-off values for predicting Type 2 diabetes were 5.6 mmol/l (101 mg/dl) for fasting plasma glucose, 6.9 mmol/l (124 mg/dl) for 2-h post-load glucose and 37 mmol/mol (5.5%) for HbA1c. In a stratified analysis, the cut-off values were approximately 5.6 mmol/l (101 mg/dl) for fasting plasma glucose and 37 mmol/mol (5.5%) for HbA1c, and these values were unchanged over BMI quartile levels, whereas the 2-h post-load glucose cut-off values declined with decreasing BMI levels. Conclusions Our findings suggest that the cut-off value for predicting Type 2 diabetes in the Japanese population is 5.6 mmol/l (101 mg/dl) for fasting plasma glucose and 37 mmol/mol (5.5%) for HbA1c, while the 2-h post-load glucose cut-off value is lower than the diagnostic criterion for impaired glucose tolerance.
- Subjects
JAPAN; TYPE 2 diabetes diagnosis; MEDICAL needs assessment; BLOOD sugar; DIABETES; FASTING; GLUCOSE tolerance tests; HEMOGLOBINS; HOMEOSTASIS; SURVEYS; BODY mass index
- Publication
Diabetic Medicine, 2012, Vol 29, Issue 1, p99
- ISSN
0742-3071
- Publication type
Article
- DOI
10.1111/j.1464-5491.2011.03378.x