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- Title
Weight gain is associated with improved glycaemic control but with adverse changes in plasma lipids and blood pressure in type 1 diabetes.
- Authors
Ferriss JB; Webb D; Chaturvedi N; Fuller JH; Idzior-Walus B
- Abstract
Aims To assess the effects of weight gain on metabolic control, plasma lipids and blood pressure in patients with Type 1 diabetes. Methods Patients in the EURODIAB Prospective Complications Study ( n = 3250) were examined at baseline and 1800 (55%) were re-examined a mean of 7.3 years later. Patients had Type 1 diabetes, defined as a diagnosis made before age 36 years and with a need for continuous insulin therapy within a year of diagnosis. Patients were aged 15-60 years at baseline and were stratified for age, sex and duration of diabetes. Results The change in HbA[1c] from baseline to follow-up examination was significantly more favourable in those who gained 5 kg or more during follow-up ('marked weight gain') than in patients who gained less or no weight or lost weight ('less or no weight gain'). In those with marked weight gain, there was a significantly greater rise in plasma triglycerides and total cholesterol and significantly less favourable changes in low-density lipoprotein and high-density lipoprotein cholesterol compared with those with less or no weight gain, with or without adjustment for HbA[1c]. Systolic and diastolic blood pressure also rose significantly more in the group with marked weight gain. Conclusion Weight gain in patients with Type 1 diabetes has adverse effects on plasma lipids and blood pressure, despite a small improvement in glycaemic control.
- Publication
Diabetic Medicine, 2006, Vol 23, Issue 5, p557
- ISSN
0742-3071
- Publication type
Journal Article
- DOI
10.1111/j.1464-5491.2006.01847.x