We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
DC‐SIGN and VDR polymorphisms are associated with chronic form of paracoccidioidomycosis with oral manifestations.
- Authors
Alves Pereira Neto, Tertuliano; Costa Pereira, Alessandro Antônio; Costa Hanemann, João Adolfo; Coelho, Luiz Felipe Leomil; Malaquias, Luiz Cosme Cotta
- Abstract
Summary: Paracoccidioidomycosis (PCM) is a granulomatous disease caused by fungi of the species complex of the Paracoccidioides genus. One of the main clinical manifestations of PCM is the presence of oral lesions with the presence of epithelioid granulomas. In this work, we aimed to evaluate the frequency of SNPs in the TNF‐α, JAK1,VDR, DC‐SIGN and FcγRIIa genes in patients with chronic PCM and verify possible association of these SNPs with the organisation pattern of the granulomas in the oral lesions. A total of 66 samples of DNA were obtained from oral lesions biopsies and 106 DNA samples were obtained from healthy individuals. The individuals were genotyped for SNPs in DC‐SIGN (rs4804803), FcγRIIa (rs1801274), JAK1 (rs11208534), TNF‐α (rs1800629) and VDR (rs7975232) by real‐time PCR and allele discrimination method. Granulomas were classified as loose or dense according to the histological pattern. In the VDR (rs7975232), the CC genotype (P < 0.001, OR = 5.94, 95% CI = 2.07‐17.05), and the C allele (P = 0.027, OR = 2.71, 95% CI = 1.07‐6.86), as well as the GG genotype in DC‐SIGN (rs4804803) (P = 0.032, OR: 3.76, 95%, I = 1.06‐13.38) are associated with an increased risk of oral PCM. Our data indicate that VDR and DC‐SIGN genetics variations are related to the susceptibility of oral PCM in the group of patients analysed.
- Subjects
PARACOCCIDIOIDOMYCOSIS; ORAL manifestations of general diseases; CHRONIC granulomatous disease; DNA; BIOPSY
- Publication
Mycoses, 2019, Vol 62, Issue 2, p186
- ISSN
0933-7407
- Publication type
Article
- DOI
10.1111/myc.12866