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- Title
Circulating naive and memory CD4+ T cells and metabolic syndrome in patients with systemic lupus erythematosus: data from a primarily Mestizo population.
- Authors
Ugarte-Gil, Manuel F.; Sánchez-Zúñiga, César; Gamboa-Cárdenas, Rocío V.; Aliaga-Zamudio, Madeley; Zevallos, Francisco; Tineo-Pozo, Giannina; Cucho-Venegas, Jorge M.; Mosqueira-Riveros, Ana; Perich-Campos, Risto A.; Alfaro-Lozano, José L.; Medina, Mariela; Rodríguez-Bellido, Zoila; Alarcón, Graciela S.; Pastor-Asurza, Cesar A.
- Abstract
Objective. The aim of this study was to determine whether the proportions of naive and memory CD4+ T cell are independently associated with the metabolic syndrome (MetS) in patients with SLE. Methods. This cross-sectional study was conducted in SLE patients seen at our rheumatology department between September 2013 and April 2014. CD4+ T cell subpopulations were examined by flow cytometry. The association of MetS and CD4+ T cell subpopulations was examined by Mann-Whitney U-test and by multivariable analysis, adjusting for all possible confounding variables. Results. One hundred and seventeen patients were evaluated. Their mean age was 44.6 years (S.D. 12.6), 109 (93.2%) were female and all patients were Mestizo (mixed Caucasian and Amerindian ancestry). Fifty-two patients (44.4%) presented with MetS. Disease duration was 7.6 years (S.D. 6.8). The percentage of naive CD4+ T cells was 25.0 (S.D. 12.7) and memory CD4+ T cells was 66.7 (S.D. 13.2) and the memory:naive CD4+ T cell ratio was 4.3 (S.D. 5.6). In multivariable analysis, the percentage of naive CD4+ T cells was negatively associated with the presence of MetS [odds ratio (OR) 0.959 (95% CI 0.923, 0.997), P=0.033], whereas the percentage of memory CD4+T cells and the memory:naive CD4+ T cell ratio were positively associated with its presence [OR 1.040 (95% CI 1.003, 1.078), P=0.031 and OR 1.238 (95% CI 1.041, 1.472), P=0.016, respectively]. Conclusion. In the SLE patients studied, a lower percentage of naive CD4+ T cells, a higher percentage of memory CD4+ T cells and the memory:naive CD4+ T cell ratio were independently associated with the presence of MetS. This association could reflect the impact of immunosenescence among SLE patients with cardiovascular morbidity.
- Subjects
PERU; ACADEMIC medical centers; BLOOD testing; CARDIOVASCULAR diseases; CHI-squared test; CONFIDENCE intervals; FLOW cytometry; IMMUNE system; NATIVE Americans; MULTIVARIATE analysis; RESEARCH funding; SYSTEMIC lupus erythematosus; T cells; LOGISTIC regression analysis; SOCIOECONOMIC factors; METABOLIC syndrome; CROSS-sectional method; DATA analysis software; DESCRIPTIVE statistics; MANN Whitney U Test
- Publication
Rheumatology, 2015, Vol 54, Issue 7, p1302
- ISSN
1462-0324
- Publication type
Article
- DOI
10.1093/rheumatology/keu434