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- Title
Pulmonary hypertension in systemic lupus erythematosus: echocardiography-based definitions predict 6-year survival.
- Authors
Hübbe-Tena, Claudia; Gallegos-Nava, Selma; Márquez-Velasco, Ricardo; Castillo-Martínez, Diana; Vargas-Barrón, Jesus; Sandoval, Julio; Amezcua-Guerra, Luis M.
- Abstract
Objective. The aim of this study was to investigate whether a core of echocardiography-based definitions of pulmonary hypertension (PH), as proposed by the European Society of Cardiology, European Respiratory Society and International Society of Heart and Lung Transplantation (ESC/ERS/ISHLT), may predict long-term survival in patients with SLE.Methods. A post hoc analysis from a cohort of SLE patients followed over 6 years was performed. Clinical associations, serum biomarkers, autoantibody profile, length of survival and all-cause mortality were assessed.Results. Out of 115 patients from the original cohort, 55 satisfied our inclusion criteria and were grouped according to echocardiography as unlikely (n = 26), possible (n = 16) or likely (n = 13) to have PH. Likely PH was associated with a history of pulmonary thromboembolism, higher cumulated organ damage and active arthritis. The 6-year survival rate was 88% in the unlikely PH group, 87% in the possible PH group and 68% in the likely PH group (P < 0.05). Serum levels of endothelin-1, monocyte chemotactic protein-1, IL-17, and IFN-γ as well as a number of autoantibodies were no different between groups.Conclusion. The ESC/ERS/ISHLT echocardiography-based definitions of PH are useful to predict 6-year mortality in SLE patients. A history of pulmonary thromboembolism and lung vasculitis/haemorrhage, cumulated organ damage and long-lasting disease are associated with PH in SLE.
- Subjects
MEXICO; SYSTEMIC lupus erythematosus; THERAPEUTIC use of biochemical markers; ACADEMIC medical centers; BLOOD testing; CHI-squared test; CONFIDENCE intervals; ECHOCARDIOGRAPHY; IMMUNOGLOBULINS; LONGITUDINAL method; MEDICAL protocols; STATISTICS; PULMONARY hypertension; SURVIVAL; DATA analysis; DATA analysis software; DESCRIPTIVE statistics; KAPLAN-Meier estimator; LOG-rank test; PROGNOSIS
- Publication
Rheumatology, 2014, Vol 53, Issue 7, p1256
- ISSN
1462-0324
- Publication type
Article
- DOI
10.1093/rheumatology/keu012