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- Title
Association between the Persistence of Obesity and the Risk of Gastric Cancer: A Nationwide Population-Based Study.
- Authors
Joo Hyun Lim; Cheol Min Shin; Kyung-Do Han; Seung Woo Lee; Eun Hyo Jin; Yoon Jin Choi; Hyuk Yoon; Young Soo Park; Nayoung Kim; Dong Ho Lee
- Abstract
Purpose There remains controversy about relationship between obesity and gastric cancer. We aimed to examine the association using obesity-persistence. Materials and Methods We analyzed a nationwide population-based cohort which underwent health check-up between 2009 and 2012. Among them, those who had annual examinations during the last 5 years were selected. Gastric cancer risk was compared between those without obesity during the 5 years (never-obesity group) and those with obesity diagnosis during the 5 years (nonpersistent obesity group; persistent obesity group). Results Among 2,757,017 individuals, 13,441 developed gastric cancer after median 6.78 years of follow-up. Gastric cancer risk was the highest in persistent obesity group (incidence rate [IR], 0.89/1,000 person-years; hazard ratio [HR], 1.197; 95% confidence interval [CI], 1.117 to 1.284), followed by non-persistent obesity group (IR, 0.83/1,000 person-years; HR, 1.113; 95% CI, 1.056 to 1.172) compared with never-obesity group. In subgroup analysis, this positive relationship was true among those < 65 years old and male. Among heavy-drinkers, the impact of obesity-persistence on the gastric cancer risk far increased (non-persistent obesity: HR, 1.297; 95% CI, 1.094 to 1.538; persistent obesity: HR, 1.351; 95% CI, 1.076 to 1.698). Conclusion Obesity-persistence is associated with increased risk of gastric cancer in a dose-response manner, especially among male < 65 years old. The risk raising effect was much stronger among heavy-drinkers.
- Subjects
STOMACH cancer; DISEASE risk factors; OBESITY; CONFIDENCE intervals; SUBGROUP analysis (Experimental design)
- Publication
Cancer Research & Treatment, 2022, Vol 54, Issue 1, p199
- ISSN
1598-2998
- Publication type
Article
- DOI
10.4143/crt.2021.130