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- Title
Development of Protocol for Korean Lung Cancer Screening Project (K-LUCAS) to Evaluate Effectiveness and Feasibility to Implement National Cancer Screening Program.
- Authors
Jaeho Lee; Juntae Lim; Yeol Kim; Hyae Young Kim; Jin Mo Goo; Choon-Taek Lee; Seung Hun Jang; Won-Chul Lee; Chan Wha Lee; Jin Young An; Ki Dong Ko; Min Ki Lee; Kui Son Choi; Boyoung Park; Duk Hyoung Lee
- Abstract
Purpose To reduce lung cancer mortality, lung cancer screening was recommended using low-dose computed tomography (LDCT) to high-risk population. A protocol for multicenter lung cancer screening pilot project was developed to evaluate the effectiveness and feasibility of lung cancer screening to implement National Cancer Screening Program in Korea. Materials and Methods Multidisciplinary expert committee was comprised to develop a standardized protocol for Korean Lung Cancer Screening Project (K-LUCAS). K-LUCAS is a population-based single arm trial that targets high-risk population aged 55-74 years with at least 30 pack-year smoking history. LDCT results are reported by Lung-RADS suggested by American Radiology Society. Network-based system using computer-aided detection program is prepared to assist reducing diagnostic errors. Smoking cessation counselling is provided to all currently smoking participants. A small pilot test was conducted to check the feasibility and compliance of the protocols for K-LUCAS. Results In pilot test, 256 were participated. The average age of participants was 63.2 years and only three participants (1.2%) were female. The participants had a smoking history of 40.5 pack-year on average and 53.9% were current smokers. Among them, 86.3% had willing to participate in lung cancer screening again. The average willingness to quit smoking among current smokers was 12.7% higher than before screening. In Lung-RADS reports, 10 (3.9%) were grade 3 and nine (3.5%) were grade 4. One participant was diagnosed as lung cancer. Conclusion The protocol developed by this study is assessed to be feasible to perform K-LUCAS in multicenter nationwide scale.
- Subjects
SOUTH Korea; EARLY detection of cancer; LUNG cancer; SMOKING cessation; DIAGNOSTIC errors; CANCER-related mortality
- Publication
Cancer Research & Treatment, 2019, Vol 51, Issue 4, p1285
- ISSN
1598-2998
- Publication type
Article
- DOI
10.4143/crt.2018.464